Umbilical venous catheterization is done 5‐10 ml aliquots are removed and replaced sequentially until about twice the blood volume of neonate has been replaced (double volume exchange transfusion)
Choice of blood:
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ABO Incompatibility: use O +ve blood. Ideal is O +ve cells suspended in AB plasma
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Rh ISO-immunization: In emergency use O ‐ve blood. Ideal is O ‐ve blood suspended in AB plasma